Chemical characterization and antifungal activity of Origanum vulgare, Thymus vulgaris essential oils and carvacrol against Malassezia furfur.
Vinciguerra V1, Rojas F2, Tedesco V3, Giusiano G2, Angiolella L3.
1 Department for Innovation in Biological, Agro-food and Forest Systems (DIBAF) University of Tuscia-Viterbo, L.go dell’Università , Viterbo , Italy
2 Departamento de Micologia , Instituto de Medicina Regional, Universidad Nacional del Nordeste, CONICET , Resistencia , Argentina.
3 Department of Public Health and Infectious Diseases , Sapienza University of Rome , Roma , Italy.
The composition of the essential oils (EOs) of O. vulgare L. EO and T. vulgaris EO, were analyzed by GC and GC-MS. Antifungal activities of the EOs and its main component, carvacrol, were evaluated against 27 clinical isolates of Malassezia furfur. Minimum inhibitory concentrations (MICs) were measured according to the broth microdilution protocols by Clinical and Laboratory Standards Institute (CLSI) modified for Malassezia spp. EOs and carvacrol showed low MIC values ranged 450-900 μg/ml against M. furfur. No differences in EOs antifungal activity were observed in sensitive to resistant fluconazole isolates. The antifungal activity obtained showed O. vulgare EO, T. vulgaris EO and carvacrol, their compound, as potential antimicrobial agents against M. furfur, yeast associated with human mycoses.
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